Cancer Decisions - Free Newsletter

HERE AT THE MOSS REPORTS

During my long career in the field of cancer I have seen many theories arrive in a blaze of glory only to be discredited and quietly discarded a short time later. By going to primary sources and carefully studying the scientific literature, I aim to provide my readers with the best possible synopsis of the current state of knowledge in the world of cancer treatment and prevention. My goal, and that of my organization, Cancer Communications, Inc., is to maintain the sort of consistent, reliably objective analytical standard that will allow my readers to make truly informed decisions.

In the past 30 years I have written and published extensively on the subject of cancer and its treatment, and have compiled a comprehensive series of more than 200 individual reports on different cancer diagnoses - The Moss Reports - each one of which examines both the standard treatment options that are likely to be offered for a particular cancer diagnosis, and the possible alternative and complementary approaches that may prove most useful.

If you would like to order a Moss Report for yourself or someone you love, you can do so securely and easily from our Web site, www.cancerdecisions.com, or by calling 1-800-980-1234 (814-238-3367 from outside the US).

I also offer phone consultations to clients who have purchased a Moss Report. A phone consultation can be enormously helpful in drawing up an effective treatment strategy and getting one's options clearly prioritized.

A recent phone consultation client wrote:

"I've used the Moss Report on Breast Cancer to direct my successful ten-year battle with the disease, and I've appreciated the thorough research and unbiased opinions that Dr. Moss provides. Since I am once again in a position that I must seek further treatment, I chose to have a phone consultation with Dr. Moss. I had been considering a treatment option that Dr. Moss felt very strongly would not be of benefit to me. Through our conversation I not only gained information that will keep me from wasting $20,000 on a treatment with no merit, but Dr. Moss also gave me some ideas that cause me to remain very hopeful." - J.M.

To schedule a phone consultation, please call 1-800-980-1234 (814-238-3367 from outside the US) or send an email to Jacquie@cancerdecisions.com.

We look forward to helping you.

CURRENT TOPICS

Also available from our Web site are our Current Topics reports - a series of in-depth reviews of important cancer-related subjects and controversies. Currently available are the following:

On Guard - Gardasil (A discussion of the anti-cervical cancer vaccine Gardasil)
Do Antioxidants and Chemotherapy Conflict?
Mammography, Biopsy and the Diagnosis of Breast Cancer
Herceptin or Deceptin? (An evaluation of the use of Herceptin in breast cancer)
Avastin: Your Money Or Your Life. (A clear-eyed look at the targeted drug Avastin)
The Politics of Hope: Andrew von Eschenbach and the Decline of the National Cancer Institute
The Mexican Cancer Clinics in the Era of Evidence-Based Medicine

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TWISTING THE RECORD ON VITAMIN D

A team of researchers led by National Cancer Institute (NCI) epidemiologist Dr. Michal Freedman has published an article suggesting that vitamin D is highly successful in reducing deaths from cancers of the colon and rectum. The researchers studied 16,818 people who had joined a nationwide U.S. government health survey between 1988 and 1994. The volunteers were then followed through the year 2000, by which time 536 had died of cancer. The study found that people with relatively high blood levels of vitamin D when they entered the study had a 72 percent reduction in their risk of dying of colorectal cancer compared to those with lower levels of vitamin D.

The article was published in the Journal of the National Cancer Institute in early November 2007 (although news of it broke a week earlier). The researchers were quoted as saying that the findings in colorectal cancer were consistent with other studies of vitamin D. On the other hand, the study did not establish a more generalized link between high levels of vitamin D and a reduction in the overall risk of dying from various cancers, including those of the lung, prostate, and breast.

There are important questions about the methodology used in this study, issues that may have limited the researchers' ability to detect some of the positive effects of vitamin D. But even if the methodology and conclusions of the Freedman study were correct, it is not so much the results that are disappointing, but the spin that the mainstream media put on the findings. The reaction of the media to the study revealed in a stark way their deeply ingrained prejudice against nutritional solutions to cancer.

The Reuters news agency did report the study correctly and with a properly nuanced understanding of its positive and negative aspects. The headline of the Reuters report read: "Vitamin D Cuts Colon Cancer Death Risk." The article, by writer Will Dunham, began: "People with higher vitamin D levels are less likely to die of colorectal cancer, researchers said on Tuesday, but the vitamin does not appear to affect the chances of dying from any other type of cancer" (Oct 31, 2007). This is a fair summary of the paper's conclusions. One other source, the Canadian Broadcasting Corp., or CDC, also got it right: "Vitamin D Cuts Colorectal Cancer Risk."

But most news outlets that I saw emphasized the negative aspect of the findings, that vitamin D, as one put it, was no "magic bullet" for cancer (as if anyone said it was). Here are some of the headlines of stories that were published hours after the news of the study first broke:

"Vitamin D May Not Reduce Cancer Deaths" (AP)
"Vitamin D May Not Lower Risk of Cancer Deaths" (Fox)
"Vitamin D Is Not Magic Bullet for Cancer" (Wired News)
"Vitamin D Won't Help Prevent Most Cancers" (HealthDay)
"Vitamin D Doesn't Prevent Cancer Deaths" (Windsor Star)
"Vitamin D Benefit At Issue" (Ft. Worth Star)
"No Connection Found Between Vitamin D and Overall Cancer Deaths" (Medical News Today)
"Vitamin D Doesn't Reduce Cancer Risk" (Nutraingredients.com)
"Vitamin D Does Not Reduce Overall Cancer Mortality" (ANI India News)
"Vitamin D Has No Effect on Overall Cancer Death Rate" (Medical News Today, 2nd article)
"Study Raises Questions About Vitamin D and Cancer" (KWWL Iowa)
"Vitamin D Downgrade As Scientists Advise There is No Real Proof It Fights Cancer" (Daily Mail)

According to the study, "Colorectal cancer mortality was inversely related to serum 25(OH)D level." (Serum 25(OH)D is a standard biochemical marker that is used to determine blood levels of vitamin D.) Participants in the study who had 25(OH)D levels of 80 nmol/L or higher had a 72 percent risk reduction in colorectal cancer compared to people who had levels lower than 50 nmol/L (Freedman 2007).

A Thought Experiment

So let us now imagine that everyone who had vitamin D levels of 50 nmol/L could be brought up to the level of 80 nmol/L. This could be accomplished through the judicious use of vitamin D supplements. Another way would be through increased sunlight exposure, although that is controversial since it might also raise the risk of some skin cancers.

The American Cancer Society anticipates that in 2007 a total of 52,180 Americans will die of colorectal cancer, representing approximately 10 percent of all cancer deaths (Cancer Facts and Figures 2007). If you prevented 72 percent of these deaths you would save 37,570 lives each year. To comprehend this graphically, the seating capacity of Fenway Park in Boston is 38,805. Thus, you could nearly fill this stadium to capacity with the people whose deaths from colorectal cancer could be avoided each and every year. Worldwide, the United Nations estimates that there are 500,000 deaths from colorectal cancer each year (W.H.O. World Cancer Report 2003). A 72 percent reduction would mean 360,000 lives saved each year. That's a lot of lives saved and a lot of misery avoided!

There is some disagreement over how much vitamin D is necessary in order to raise the blood level to 80 nmol/L. As a general rule, the government advocates the intake of 400 IU vitamin D per day. But some Canadian experts feel that a minimum of 800 IU/day to 1000 IU/day may be needed, with up to 2000 IU/day to 4000 IU/day in special circumstances (Canadian Pediatric Society 2007).

One hundred tablets of 800 IU of vitamin D can be purchased on the Internet for under $2.00 ($1.94). Thus, most people could supply themselves with sufficient amounts of supplemental vitamin D for 2¢ per day, or around $7.50 per year. By comparison, Leonard Saltz, M.D., an expert on colon cancer treatment at Memorial Sloan-Kettering Cancer Center, N.Y., has estimated that the cost of chemotherapy for advanced colon cancer is approximately $250,000. Thus the cost of treating just one case of colon cancer would be enough to prevent death from colon cancer in over 30,000 cases. This is a perspective that somehow failed to come across in the vast majority of recent media stories about vitamin D and cancer.

--Ralph W. Moss, Ph.D.

References:

Canadian Pediatric Society: Vitamin D supplementation: Recommendations for Canadian mothers and infants. Accessed at:
http://www.cps.ca/english/statements/II/FNIM07-01.htm

Cost of cancer treatment:
http://www.usatoday.com/news/health/2006-07-10-cancer-costs_x.htm

Freedman DM, Looker AC, Chang SC, et al. Prospective study of serum vitamin D and cancer mortality in the United States. J Natl Cancer Inst 2007 Nov 7;99(21):1594-602.

W.H.O. World Cancer Report:
http://www.who.int/mediacentre/news/releases/2003/pr27/en/

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IMPORTANT DISCLAIMER

The news and other items in this newsletter are intended for informational purposes only. Nothing in this newsletter is intended to be a substitute for professional medical advice.